منابع مشابه
Heparin biosynthesis.
Heparin and heparan sulfate share the same polysaccharide backbone structure but differ in sulfation degree and expression pattern. Whereas heparan sulfate is found in virtually all cells of the human body, heparin expression is restricted to mast cells, where it has a function in storage of granular components such as histamine and mast cell specific proteases. Although differing in charge and...
متن کاملBiosynthesis of Heparin
Microsomal fraction from mouse mastocytoma was incubated for 60 min with UDP-[Wlglucuronic acid and unlabeled UDP-N-acetylglucosamine, producing nonsulfated labeled polysaccharide. Continued incubation for an additional 60-min period, in the presence of 3’-phosphoadenylylsulfate, yielded sulfated, heparin-like polymer. The incorporation of W was terminated at the beginning of the sulfation peri...
متن کاملBiosynthesis of Heparin
Microsomal fraction from mouse mastocytoma was incubated for 60 min with UDP-[Wlglucuronic acid and unlabeled UDP-N-acetylglucosamine, producing nonsulfated labeled polysaccharide. Continued incubation for an additional 60-min period, in the presence of 3’-phosphoadenylylsulfate, yielded sulfated, heparin-like polymer. The incorporation of W was terminated at the beginning of the sulfation peri...
متن کاملHeparin induced thrombocytopenia
Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...
متن کاملBiosynthesis of heparin/heparan sulphate: mechanism of epimerization of glucuronyl C-5.
In the biosynthesis of heparin and heparan sulphate, D-glucuronic acid residues are converted into L-iduronic acid (IdoA) units by C-5 epimerization, at the polymer level. The reaction catalysed by the epimerase occurs by reversible abstraction and readdition of a proton at C-5 of target hexuronic acid residues, through a carbanion intermediate, with or without an inversion of configuration at ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)43383-8